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1. Injury of vascular wall the lumen surface of vascular wall is covered by endothelial cells, Normal vascular endothelial cells with a total area of more than 1000m2 have antithrombotic properties, It passes through a negative surface charge, Release various substances, such as ATPase ADP enzyme, tissue plasminogen activator (tpA), thrombin regulatory protein (TM), tissue factor pathway inhibitor (TFPI), endothelium derived relaxation factor (EDRF) PGI2 and other substances, prevent platelet adhesion and aggregation, promote fibrinolysis, inhibit blood coagulation process, enhance anticoagulation, and achieve the effects of maintaining blood fluidity and preventing thrombosis.The essence of these 23 design patterns is the practical application of object-oriented design principles, and it is a full understanding of the encapsulation, inheritance and polymorphism of classes, as well as the association and combination of classes.道光十九年，道光帝为除“三害”，命林则徐赴广州禁烟，两江总督陶澍整顿盐政，又命户部侍郎爱新觉罗•铁麟为仓场总督，赴通州漕运码头铲除日益猖獗、积重难返的漕弊。漕运码头上官衙林立，文武交织，三教九流，盘根错节，形成了一个贪污腐败、危机四布、黑幕重重的独立王国。铁麟乃宗室贵胄，为了不负圣恩，重塑先祖辉煌，他口衔天宪，上任伊始即大刀阔斧地清弊惩奸，以期建功立名。户部尚书王鼎对铲除漕弊早有准备，几年前就在坐粮厅安插了心腹，并收集了武英殿大学士穆彰阿一手遮天，贪污漕粮巨款的确凿证据。然而，线人黄槐岸的神秘失踪、坐粮厅汉厅承许良年的阴险歹毒、青帮头目周三爷的呼风唤雨，通州知州夏雨轩的运筹巧计，服侍铁麟的奶妈韩小月的神秘身世以及江湖巫医唐大姑的若隐若现，却将漕运码头搅得雾障迷离，悬疑丛生。就在铁麟舍身舍名力挽沉疴之际，其爱女甘戎及不肖子甘瑞又从黑白两道搅进了漕运码头，从而引发了一系列怪异诡秘乃至人命大案。漕运码头上，一场针锋相对的生死搏杀就此展开。东方不败看着白绫上素雅柔和、温柔如水的女人。在异世界恩特·伊斯拉，虽然是敌人之间的魔王和勇者在现代日本东京，依然汗流浃背地工作着的真奥贞夫和游佐惠美。In the historical substitution principle, the methods of the subclass to the parent class should not be overridden or overloaded as far as possible. Because the parent class represents a well-defined structure, subclasses should not destroy it casually by interacting with the outside world through this standardized interface.